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Dapotime tablets are used to treat premature ejaculation (PE), which is one of the most common causes of sexual dysfunction in men. It is defined as early ejaculation with minimal sexual stimulation before of soon after penetration and can cause distress and problems with relationships. Dapotime is used to improve control over ejaculation and increase the time interval before ejaculation occurs during intercourse, for men with persistent or recurrent PE. How does Dapotime work? Dapotime tablets contain dapoxetine 60mg, a selective serotonin reuptake inhibitor (SSRI) that is used specifically for premature ejaculation (PE), as it has a rapid onset of action, with maximum effect within 1-2 hours and a short half-life, which means that it is rapidly eliminated from the body within 24 hours. Ejaculation is a reflex that is mediated by the sympathetic nervous system. When sexual stimulation has reached a certain threshold, sensory nerve cells in the spinal cord are activated and nerve impulses are sent to the brain, which then send messages back to motor neurones controlling the muscles in the penis that contract to effect ejaculation. The ejaculation reflex is thought to be mediated by serotonin, a specific brain chemical or neurotransmitter that is involved is transmitting nerve signals, which enables brain cells to communicate. Low levels of serotonin in certain areas of the brain are thought to be responsible for causing PE. Dapoxetine in Dapotime blocks the reuptake of serotonin from the synapse, which is the gap between nerve cells across which chemical messages are sent from one nerve cell to another. If the re-uptake of serotonin by the first nerve cell (pre-synaptic) is blocked, this means that there is more serotonin remaining for the receiving nerve cell (post-synaptic), which allows nerve cells to communicate with each other for longer. This action of dapoxetine in Dapotime 60 helps prolong the ability to maintain sexual activity without premature ejaculation and maintain control over ejaculation for longer. What does Dapotime contain? Dapotime tablets contain active ingredient dapoxetine, a selective serotonin reuptake inhibitor (SSRI) that is used to treat and prevent persistent or recurrent premature ejaculation (PE). Treating premature ejaculation with Dapotime Dapotime tablets contain dapoxetine 60mg, which is a selective serotonin reuptake inhibitor (SSRI) that is used specifically for treating premature ejaculation (PE), a common form sexual dysfunction in men. PE is defined as early ejaculation with minimal sexual stimulation before of soon after penetration and can cause distress and problems with relationships. The ejaculation reflex is thought to be mediated by serotonin, a specific brain chemical or neurotransmitter that is involved is transmitting nerve signals, which enables brain cells to communicate. Low levels of serotonin in certain areas of the brain are thought to be responsible for causing ED. Dapoxetine in Dapotime blocks the reuptake of serotonin from the synapse, which is the gap between nerve cells across which chemical messages are sent from one nerve cell to another. If the re-uptake of serotonin by the first nerve cell (pre-synaptic) is blocked, this means that there is more serotonin remaining for the receiving nerve cell (post-synaptic), which allows nerve cells to communicate with each other for longer. Dapoxetine in Dapotime helps improve control over ejaculation and increase the time interval before ejaculation occurs during intercourse, for men with persistent or recurrent PE. What are the side effects of Dapotime? The most commonly reported side effects when taking Dapotime tablets include, headache, gastrointestinal upset (nausea, diarrhoea, dry mouth, abdominal discomfort), dizziness, drowsiness, tremor, difficulty sleeping, increased blood pressure, erectile dysfunction, reduced libido. When should Dapotime not be used? You should not use Dapotime tablets if you: are allergic to dapoxetine or any ingredients in Dapotime have severe liver or kidney disease have a heart condition or heart failure have a bleeding disorder have a history of orthostatic hypotension (dizziness when standing up), without discussion with your doctor have depression, bipolar disorder, unstable epilepsy or schizophrenia are taking any monoamine oxidase inhibitor medications as these can cause serious reactions if taken with Dapotime or within 14 days are taking medicines that interact with Dapotime, including: thioridazine for schizophrenia, monoamine oxidase inhibitors (MAOIs) for depression, migraine medicines like sumatriptan, the analgesic tramadol, SSRI antidepressants like paroxetine or citalopram, SNRI antidepressants like venlafaxine, lithium for mood disorders, calcium channel blockers like diltiazem for hypertension, the anticoagulant warfarin, HIV treatments like ritonavir and atazanavir, antifungals like ketoconazole, antibiotics like erythromycin, NSAIDs like aspirin or ibuprofen, herbal remedies containing St. John´s Wort What medications interact with Dapotime? Several medications interact with Dapotime tablets and should either not be taken while you are taking Dapotime or only after discussion and instruction from your doctor: Drugs that cause a serious reaction with Dapotime: monoamine oxidase inhibitors for depression, thioridazine for schizophrenia, the anticoagulant warfarin increases risk of bleeding, NSAIDs like aspirin or ibuprofen St. John´s Wort, migraine medicines like sumatriptan, the analgesic tramadol, SSRI antidepressants like paroxetine or citalopram, SNRI antidepressants like venlafaxine, lithium for mood disorders, Drugs that affect Dapotime: thioridazine for schizophrenia, antifungals like ketoconazole, antibiotics like erythromycin, HIV treatments like ritonavir and atazanavir, calcium channel blockers like diltiazem for hypertension How should Dapotime be taken? You should take your Dapotime tablets swallowed whole with a glass of water with or without food. You should take your Dapotime 60 1-3 hours before planned sexual activity. You should not take more than one tablet of Dapotime 60 in 24 hours and avoid alcohol. How should Dapotime be stored? You should store your Dapotime tablets below 25°C in a cool dry place.